High ALDH Activity Identifies Chemotherapy-Resistant Ewing's Sarcoma Stem Cells That Retain Sensitivity to EWS-FLI1 Inhibition

BACKGROUND: Cancer stem cells are a chemotherapy-resistant population capable of self-renewal and of regenerating the bulk tumor, thereby causing relapse and patient death. Ewing's sarcoma, the second most common form of bone tumor in adolescents and young adults, follows a clinical pattern con...

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Detalles Bibliográficos
Autores principales: Awad, Ola, Yustein, Jason T., Shah, Preeti, Gul, Naheed, Katuri, Varalakshmi, O'Neill, Alison, Kong, Yali, Brown, Milton L., Toretsky, Jeffrey A., Loeb, David M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978678/
https://www.ncbi.nlm.nih.gov/pubmed/21085683
http://dx.doi.org/10.1371/journal.pone.0013943

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978678/
https://www.ncbi.nlm.nih.gov/pubmed/21085683
http://dx.doi.org/10.1371/journal.pone.0013943

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