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α-Actinin-4 Is Essential for Maintaining the Spreading, Motility and Contractility of Fibroblasts
BACKGROUND: α-Actinins cross-link actin filaments, with this cross-linking activity regulating the formation of focal adhesions, intracellular tension, and cell migration. Most non-muscle cells such as fibroblasts express two isoforms, α-actinin-1 (ACTN1) and α-actinin-4 (ACTN4). The high homology b...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978680/ https://www.ncbi.nlm.nih.gov/pubmed/21085685 http://dx.doi.org/10.1371/journal.pone.0013921 |