Thermodynamic Additivity of Sequence Variations: An Algorithm for Creating High Affinity Peptides Without Large Libraries or Structural Information

BACKGROUND: There is a significant need for affinity reagents with high target affinity/specificity that can be developed rapidly and inexpensively. Existing affinity reagent development approaches, including protein mutagenesis, directed evolution, and fragment-based design utilize large libraries...

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Detalles Bibliográficos
Autores principales: Greving, Matthew P., Belcher, Paul E., Diehnelt, Chris W., Gonzalez-Moa, Maria J., Emery, Jack, Fu, Jinglin, Johnston, Stephen Albert, Woodbury, Neal W.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978705/
https://www.ncbi.nlm.nih.gov/pubmed/21085650
http://dx.doi.org/10.1371/journal.pone.0015432

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978705/
https://www.ncbi.nlm.nih.gov/pubmed/21085650
http://dx.doi.org/10.1371/journal.pone.0015432

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