Ethyl 6-[4-(dimethyl­amino)phen­yl]-4-hydr­oxy-2-oxo-4-(trifluoro­methyl)­hexa­hydro­pyrimidine-5-carboxyl­ate

The title compound, C(16)H(20)F(3)N(3)O(4), was prepared by reaction of 4-(dimethyl­amino)benzaldehyde, ethyl 4,4,4-trifluoro-3-oxo­butanoate and urea. In the title mol­ecule, the pyrimidine ring adopts a half-chair conformation and there is an intra­molecular hydrogen bond (O—H⋯O). The crystal stru...

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Detalles Bibliográficos
Autores principales: Song, Xiao-Ping, Li, Gong-Chun, Wu, Chang-Zeng, Yang, Feng-Ling
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2010
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2979242/
https://www.ncbi.nlm.nih.gov/pubmed/21579137
http://dx.doi.org/10.1107/S1600536810013127
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author Song, Xiao-Ping
Li, Gong-Chun
Wu, Chang-Zeng
Yang, Feng-Ling
author_facet Song, Xiao-Ping
Li, Gong-Chun
Wu, Chang-Zeng
Yang, Feng-Ling
author_sort Song, Xiao-Ping
collection PubMed
description The title compound, C(16)H(20)F(3)N(3)O(4), was prepared by reaction of 4-(dimethyl­amino)benzaldehyde, ethyl 4,4,4-trifluoro-3-oxo­butanoate and urea. In the title mol­ecule, the pyrimidine ring adopts a half-chair conformation and there is an intra­molecular hydrogen bond (O—H⋯O). The crystal structure is stabilized by two types inter­molecular hydrogen bonds (N—H⋯O and N—H⋯N).
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spelling pubmed-29792422010-12-30 Ethyl 6-[4-(dimethyl­amino)phen­yl]-4-hydr­oxy-2-oxo-4-(trifluoro­methyl)­hexa­hydro­pyrimidine-5-carboxyl­ate Song, Xiao-Ping Li, Gong-Chun Wu, Chang-Zeng Yang, Feng-Ling Acta Crystallogr Sect E Struct Rep Online Organic Papers The title compound, C(16)H(20)F(3)N(3)O(4), was prepared by reaction of 4-(dimethyl­amino)benzaldehyde, ethyl 4,4,4-trifluoro-3-oxo­butanoate and urea. In the title mol­ecule, the pyrimidine ring adopts a half-chair conformation and there is an intra­molecular hydrogen bond (O—H⋯O). The crystal structure is stabilized by two types inter­molecular hydrogen bonds (N—H⋯O and N—H⋯N). International Union of Crystallography 2010-04-14 /pmc/articles/PMC2979242/ /pubmed/21579137 http://dx.doi.org/10.1107/S1600536810013127 Text en © Song et al. 2010 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Song, Xiao-Ping
Li, Gong-Chun
Wu, Chang-Zeng
Yang, Feng-Ling
Ethyl 6-[4-(dimethyl­amino)phen­yl]-4-hydr­oxy-2-oxo-4-(trifluoro­methyl)­hexa­hydro­pyrimidine-5-carboxyl­ate
title Ethyl 6-[4-(dimethyl­amino)phen­yl]-4-hydr­oxy-2-oxo-4-(trifluoro­methyl)­hexa­hydro­pyrimidine-5-carboxyl­ate
title_full Ethyl 6-[4-(dimethyl­amino)phen­yl]-4-hydr­oxy-2-oxo-4-(trifluoro­methyl)­hexa­hydro­pyrimidine-5-carboxyl­ate
title_fullStr Ethyl 6-[4-(dimethyl­amino)phen­yl]-4-hydr­oxy-2-oxo-4-(trifluoro­methyl)­hexa­hydro­pyrimidine-5-carboxyl­ate
title_full_unstemmed Ethyl 6-[4-(dimethyl­amino)phen­yl]-4-hydr­oxy-2-oxo-4-(trifluoro­methyl)­hexa­hydro­pyrimidine-5-carboxyl­ate
title_short Ethyl 6-[4-(dimethyl­amino)phen­yl]-4-hydr­oxy-2-oxo-4-(trifluoro­methyl)­hexa­hydro­pyrimidine-5-carboxyl­ate
title_sort ethyl 6-[4-(dimethyl­amino)phen­yl]-4-hydr­oxy-2-oxo-4-(trifluoro­methyl)­hexa­hydro­pyrimidine-5-carboxyl­ate
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2979242/
https://www.ncbi.nlm.nih.gov/pubmed/21579137
http://dx.doi.org/10.1107/S1600536810013127
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AT ligongchun ethyl64dimethylaminophenyl4hydroxy2oxo4trifluoromethylhexahydropyrimidine5carboxylate
AT wuchangzeng ethyl64dimethylaminophenyl4hydroxy2oxo4trifluoromethylhexahydropyrimidine5carboxylate
AT yangfengling ethyl64dimethylaminophenyl4hydroxy2oxo4trifluoromethylhexahydropyrimidine5carboxylate

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