RhoH Regulates Subcellular Localization of ZAP-70 and Lck in T Cell Receptor Signaling

RhoH is an hematopoietic-specific, GTPase-deficient Rho GTPase that plays a role in T development. We investigated the mechanisms of RhoH function in TCR signaling. We found that the association between Lck and CD3ζ was impaired in RhoH-deficient T cells, due to defective translocation of both Lck a...

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Detalles Bibliográficos
Autores principales: Chae, Hee-Don, Siefring, Jamie E., Hildeman, David A., Gu, Yi, Williams, David A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2980477/
https://www.ncbi.nlm.nih.gov/pubmed/21103055
http://dx.doi.org/10.1371/journal.pone.0013970

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2980477/
https://www.ncbi.nlm.nih.gov/pubmed/21103055
http://dx.doi.org/10.1371/journal.pone.0013970

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