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RhoH Regulates Subcellular Localization of ZAP-70 and Lck in T Cell Receptor Signaling
RhoH is an hematopoietic-specific, GTPase-deficient Rho GTPase that plays a role in T development. We investigated the mechanisms of RhoH function in TCR signaling. We found that the association between Lck and CD3ζ was impaired in RhoH-deficient T cells, due to defective translocation of both Lck a...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2980477/ https://www.ncbi.nlm.nih.gov/pubmed/21103055 http://dx.doi.org/10.1371/journal.pone.0013970 |