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Single-Molecule Analysis Reveals the Kinetics and Physiological Relevance of MutL-ssDNA Binding
DNA binding by MutL homologs (MLH/PMS) during mismatch repair (MMR) has been considered based on biochemical and genetic studies. Bulk studies with MutL and its yeast homologs Mlh1-Pms1 have suggested an integral role for a single-stranded DNA (ssDNA) binding activity during MMR. We have developed s...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2980497/ https://www.ncbi.nlm.nih.gov/pubmed/21103398 http://dx.doi.org/10.1371/journal.pone.0015496 |