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Single-Molecule Analysis Reveals the Kinetics and Physiological Relevance of MutL-ssDNA Binding

DNA binding by MutL homologs (MLH/PMS) during mismatch repair (MMR) has been considered based on biochemical and genetic studies. Bulk studies with MutL and its yeast homologs Mlh1-Pms1 have suggested an integral role for a single-stranded DNA (ssDNA) binding activity during MMR. We have developed s...

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Detalles Bibliográficos
Autores principales:	Park, Jonghyun, Jeon, Yongmoon, In, Daekil, Fishel, Richard, Ban, Changill, Lee, Jong-Bong
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2980497/ https://www.ncbi.nlm.nih.gov/pubmed/21103398 http://dx.doi.org/10.1371/journal.pone.0015496

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