Matrix Rigidity Induces Osteolytic Gene Expression of Metastatic Breast Cancer Cells

Nearly 70% of breast cancer patients with advanced disease will develop bone metastases. Once established in bone, tumor cells produce factors that cause changes in normal bone remodeling, such as parathyroid hormone-related protein (PTHrP). While enhanced expression of PTHrP is known to stimulate o...

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Detalles Bibliográficos
Autores principales: Ruppender, Nazanin S., Merkel, Alyssa R., Martin, T. John, Mundy, Gregory R., Sterling, Julie A., Guelcher, Scott A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981576/
https://www.ncbi.nlm.nih.gov/pubmed/21085597
http://dx.doi.org/10.1371/journal.pone.0015451

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981576/
https://www.ncbi.nlm.nih.gov/pubmed/21085597
http://dx.doi.org/10.1371/journal.pone.0015451

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