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Antizyme Restrains Centrosome Amplification by Regulating the Accumulation of Mps1 at Centrosomes
Extra centrosomes are found in many tumors, and their appearance is an early event that can generate aberrant mitotic spindles and aneuploidy. Because the failure to appropriately degrade the Mps1 protein kinase correlates with centrosome overproduction in tumor-derived cells, defects in the factors...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2982088/ https://www.ncbi.nlm.nih.gov/pubmed/20861309 http://dx.doi.org/10.1091/mbc.E10-04-0281 |