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Protein Kinase D–mediated Phosphorylation of Polycystin-2 (TRPP2) Is Essential for Its Effects on Cell Growth and Calcium Channel Activity

PKD2 is mutated in 15% of patients with autosomal dominant polycystic kidney disease. The PKD2 protein, polycystin-2 or TRPP2, is a nonselective Ca(2+)-permeable cation channel that has been shown to function at several locations, including primary cilia, basolateral membrane, and at the endoplasmic...

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Detalles Bibliográficos
Autores principales: Streets, Andrew J., Needham, Andrew J., Gill, Sharonjit K., Ong, Albert C. M.
Formato: Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2982124/
https://www.ncbi.nlm.nih.gov/pubmed/20881056
http://dx.doi.org/10.1091/mbc.E10-04-0377