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Protein Kinase D–mediated Phosphorylation of Polycystin-2 (TRPP2) Is Essential for Its Effects on Cell Growth and Calcium Channel Activity
PKD2 is mutated in 15% of patients with autosomal dominant polycystic kidney disease. The PKD2 protein, polycystin-2 or TRPP2, is a nonselective Ca(2+)-permeable cation channel that has been shown to function at several locations, including primary cilia, basolateral membrane, and at the endoplasmic...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2982124/ https://www.ncbi.nlm.nih.gov/pubmed/20881056 http://dx.doi.org/10.1091/mbc.E10-04-0377 |