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Structural bases for the interaction of frataxin with the central components of iron–sulphur cluster assembly

Reduced levels of frataxin, an essential protein of as yet unknown function, are responsible for causing the neurodegenerative pathology Friedreich's ataxia. Independent reports have linked frataxin to iron–sulphur cluster assembly through interactions with the two central components of this ma...

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Detalles Bibliográficos
Autores principales: Prischi, Filippo, Konarev, Petr V., Iannuzzi, Clara, Pastore, Chiara, Adinolfi, Salvatore, Martin, Stephen R., Svergun, Dmitri I., Pastore, Annalisa
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2982165/
https://www.ncbi.nlm.nih.gov/pubmed/20981023
http://dx.doi.org/10.1038/ncomms1097