Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone

Cytosolic HSP90 requires multiple cochaperones in folding client proteins. However, the function of gp96 (HSP90b1, grp94), an HSP90 paralogue in the endoplasmic reticulum (ER), is believed to be independent of cochaperones. Here, we demonstrate that gp96 chaperones multiple Toll-like receptors (TLRs...

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Detalles Bibliográficos
Autores principales: Liu, Bei, Yang, Yi, Qiu, Zhijuan, Staron, Matthew, Hong, Feng, Li, Yi, Wu, Shuang, Li, Yunfeng, Hao, Bing, Bona, Robert, Han, David, Li, Zihai
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2982182/
https://www.ncbi.nlm.nih.gov/pubmed/20865800
http://dx.doi.org/10.1038/ncomms1070

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2982182/
https://www.ncbi.nlm.nih.gov/pubmed/20865800
http://dx.doi.org/10.1038/ncomms1070

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