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A Post-Burst Afterdepolarization Is Mediated by Group I Metabotropic Glutamate Receptor-Dependent Upregulation of Ca(v)2.3 R-Type Calcium Channels in CA1 Pyramidal Neurons

Activation of group I metabotropic glutamate receptors (subtypes mGluR1 and mGluR5) regulates neural activity in a variety of ways. In CA1 pyramidal neurons, activation of group I mGluRs eliminates the post-burst afterhyperpolarization (AHP) and produces an afterdepolarization (ADP) in its place. He...

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Detalles Bibliográficos
Autores principales: Park, Jin-Yong, Remy, Stefan, Varela, Juan, Cooper, Donald C., Chung, Sungkwon, Kang, Ho-Won, Lee, Jung-Ha, Spruston, Nelson
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2982802/
https://www.ncbi.nlm.nih.gov/pubmed/21103408
http://dx.doi.org/10.1371/journal.pbio.1000534