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Alterations in mGluR5 Expression and Signaling in Lewy Body Disease and in Transgenic Models of Alpha-Synucleinopathy – Implications for Excitotoxicity

Dementia with Lewy bodies (DLB) and Parkinson's Disease (PD) are neurodegenerative disorders of the aging population characterized by the abnormal accumulation of alpha-synuclein (alpha-syn). Previous studies have suggested that excitotoxicity may contribute to neurodegeneration in these disord...

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Detalles Bibliográficos
Autores principales: Price, Diana L., Rockenstein, Edward, Ubhi, Kiren, Phung, Van, MacLean-Lewis, Natalie, Askay, David, Cartier, Anna, Spencer, Brian, Patrick, Christina, Desplats, Paula, Ellisman, Mark H., Masliah, Eliezer
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2982819/
https://www.ncbi.nlm.nih.gov/pubmed/21103359
http://dx.doi.org/10.1371/journal.pone.0014020