PIASy-dependent SUMOylation regulates DNA topoisomerase IIα activity

DNA topoisomerase IIα (TopoIIα) is an essential chromosome-associated enzyme with activity implicated in the resolution of tangled DNA at centromeres before anaphase onset. However, the regulatory mechanism of TopoIIα activity is not understood. Here, we show that PIASy-mediated small ubiquitin-like...

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Detalles Bibliográficos
Autores principales: Ryu, Hyunju, Furuta, Maiko, Kirkpatrick, Donald, Gygi, Steven P., Azuma, Yoshiaki
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2983052/
https://www.ncbi.nlm.nih.gov/pubmed/21079245
http://dx.doi.org/10.1083/jcb.201004033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2983052/
https://www.ncbi.nlm.nih.gov/pubmed/21079245
http://dx.doi.org/10.1083/jcb.201004033

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