Genotoxic mechanisms for the carcinogenicity of the environmental pollutants and carcinogens o-anisidine and 2-nitroanisole follow from adducts generated by their metabolite N-(2-methoxyphenyl)-hydroxylamine with deoxyguanosine in DNA

An aromatic amine, o-anisidine (2-methoxyaniline) and its oxidative counterpart, 2-nitroanisole (2-methoxynitrobenzene), are the industrial and environmental pollutants causing tumors of the urinary bladder in rats and mice. Both carcinogens are activated to the same proximate carcinogenic metabolit...

Descripción completa

Detalles Bibliográficos
Autores principales: Stiborová, Marie, Naiman, Karel, Martínková, Markéta, Martínek, Václav, Svobodová, Martina, Schmeiser, Heinz H., Frei, Eva
Formato: Texto
Lenguaje:English
Publicado: Slovak Toxicology Society SETOX 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984092/
https://www.ncbi.nlm.nih.gov/pubmed/21217841
http://dx.doi.org/10.2478/v10102-009-0004-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984092/
https://www.ncbi.nlm.nih.gov/pubmed/21217841
http://dx.doi.org/10.2478/v10102-009-0004-4

Ejemplares similares