Histone deacetylase inhibitors valproate and trichostatin A are toxic to neuroblastoma cells and modulate cytochrome P450 1A1, 1B1 and 3A4 expression in these cells

Histone deacetylase inhibitors such as valproic acid (VPA) and trichostatin A (TSA) were shown to exert antitumor activity. Here, the toxicity of both drugs to human neuroblastoma cell lines was investigated using MTT test, and IC50 values for both compounds were determined. Another target of this w...

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Detalles Bibliográficos
Autores principales: Hřebačková, Jana, Poljaková, Jitka, Eckschlager, Tomáš, Hraběta, Jan, Procházka, Pavel, Smutný, Svatopluk, Stiborová, Marie
Formato: Texto
Lenguaje:English
Publicado: Slovak Toxicology Society SETOX 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984103/
https://www.ncbi.nlm.nih.gov/pubmed/21217856
http://dx.doi.org/10.2478/v10102-009-0019-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984103/
https://www.ncbi.nlm.nih.gov/pubmed/21217856
http://dx.doi.org/10.2478/v10102-009-0019-x

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