Hypoxia-dependent sequestration of an oxygen sensor by a widespread structural motif can shape the hypoxic response - a predictive kinetic model

BACKGROUND: The activity of the heterodimeric transcription factor hypoxia inducible factor (HIF) is regulated by the post-translational, oxygen-dependent hydroxylation of its α-subunit by members of the prolyl hydroxylase domain (PHD or EGLN)-family and by factor inhibiting HIF (FIH). PHD-dependent...

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Detalles Bibliográficos
Autores principales: Schmierer, Bernhard, Novák, Béla, Schofield, Christopher J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984394/
https://www.ncbi.nlm.nih.gov/pubmed/20955552
http://dx.doi.org/10.1186/1752-0509-4-139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984394/
https://www.ncbi.nlm.nih.gov/pubmed/20955552
http://dx.doi.org/10.1186/1752-0509-4-139

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