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Correlation between sequence conservation and structural thermodynamics of microRNA precursors from human, mouse, and chicken genomes

BACKGROUND: Previous studies have shown that microRNA precursors (pre-miRNAs) have considerably more stable secondary structures than other native RNAs (tRNA, rRNA, and mRNA) and artificial RNA sequences. However, pre-miRNAs with ultra stable secondary structures have not been investigated. It is no...

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Detalles Bibliográficos
Autores principales: Ni, Ming, Shu, Wenjie, Bo, Xiaochen, Wang, Shengqi, Li, Songgang
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984420/
https://www.ncbi.nlm.nih.gov/pubmed/20977776
http://dx.doi.org/10.1186/1471-2148-10-329