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Primary and Malignant Cholangiocytes Undergo CD40 Mediated Fas Dependent Apoptosis, but Are Insensitive to Direct Activation with Exogenous Fas Ligand

INTRODUCTION: Cholangiocarcinoma is a rare malignancy of the biliary tract, the incidence of which is rising, but the pathogenesis of which remains uncertain. No common genetic defects have been described but it is accepted that chronic inflammation is an important contributing factor. We have shown...

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Detalles Bibliográficos
Autores principales: Humphreys, Elizabeth H., Williams, Kevin T., Adams, David H., Afford, Simon C.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984448/
https://www.ncbi.nlm.nih.gov/pubmed/21103345
http://dx.doi.org/10.1371/journal.pone.0014037