Obesity-linked phosphorylation of PPARγ by cdk5 is a direct target of the anti-diabetic PPARγ ligands

Obesity induced in mice by high-fat feeding activates the protein kinase cdk5 in adipose tissues. This results in phosphorylation of the nuclear receptor PPARγ, a dominant regulator of adipogenesis and fat cell gene expression, at serine 273. This modification of PPARγ does not alter its adipogenic...

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Detalles Bibliográficos
Autores principales: Choi, Jang Hyun, Banks, Alexander S., Estall, Jennifer L., Kajimura, Shingo, Bostrom, Pontus, Laznik, Dina, Ruas, Jorge L., Chalmers, Michael J., Kamenecka, Theodore M., Bluher, Matthias, Griffin, Patrick R., Spiegelman, Bruce M.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987584/
https://www.ncbi.nlm.nih.gov/pubmed/20651683
http://dx.doi.org/10.1038/nature09291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987584/
https://www.ncbi.nlm.nih.gov/pubmed/20651683
http://dx.doi.org/10.1038/nature09291

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