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Comparison of anti-CD3 and anti-CD28-coated beads with soluble anti-CD3 for expanding human T cells: Differing impact on CD8 T cell phenotype and responsiveness to restimulation

BACKGROUND: The ability to expand virus- or tumor-specific T cells without damaging their functional capabilities is critical for success adoptive transfer immunotherapy of patients with opportunistic infection or tumor. Careful comparisons can help identify expansion methods better suited for parti...

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Detalles Bibliográficos
Autores principales: Li, Yixin, Kurlander, Roger J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987859/
https://www.ncbi.nlm.nih.gov/pubmed/20977748
http://dx.doi.org/10.1186/1479-5876-8-104