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Mcm10 proteolysis initiates before the onset of M-phase
BACKGROUND: Mcm10 protein is essential for initiation and elongation phases of replication. Human cells proteolyze Mcm10 during mitosis, presumably to ensure a single round of replication. It has been proposed that anaphase promoting complex ubiquitinates Mcm10 in late M and early G(1 )phases. RESUL...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987893/ https://www.ncbi.nlm.nih.gov/pubmed/20979666 http://dx.doi.org/10.1186/1471-2121-11-84 |