Mutant Huntingtin Alters Cell Fate in Response to Microtubule Depolymerization via the GEF-H1-RhoA-ERK Pathway

Cellular responses to drug treatment show tremendous variations. Elucidating mechanisms underlying these variations is critical for predicting therapeutic responses and developing personalized therapeutics. Using a small molecule screening approach, we discovered how a disease causing allele leads t...

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Detalles Bibliográficos
Autores principales: Varma, Hemant, Yamamoto, Ai, Sarantos, Melissa R., Hughes, Robert E., Stockwell, Brent R.
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988350/
https://www.ncbi.nlm.nih.gov/pubmed/20858895
http://dx.doi.org/10.1074/jbc.M110.125542

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988350/
https://www.ncbi.nlm.nih.gov/pubmed/20858895
http://dx.doi.org/10.1074/jbc.M110.125542

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