Exogenous IFN-γ ex vivo shapes the alloreactive T-cell repertoire by inhibition of Th17 responses and generation of functional Foxp3(+) regulatory T cells

Interferon (IFN)-γ was originally characterized as a pro-inflammatory cytokine with T helper type 1-inducing activity, but subsequent work has demonstrated that mice deficient in IFN-γ or IFN-γ receptor show exacerbated inflammatory responses and accelerated allograft rejection, suggesting that IFN-...

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Detalles Bibliográficos
Autores principales: Feng, Gang, Gao, Wenda, Strom, Terry B, Oukka, Mohamed, Francis, Ross S, Wood, Kathryn J, Bushell, Andrew
Formato: Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2008
Materias:
Immunomodulation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988413/
https://www.ncbi.nlm.nih.gov/pubmed/18792404
http://dx.doi.org/10.1002/eji.200838411

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988413/
https://www.ncbi.nlm.nih.gov/pubmed/18792404
http://dx.doi.org/10.1002/eji.200838411

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