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Smoking-mediated up-regulation of GAD67 expression in the human airway epithelium

BACKGROUND: The production of gamma-amino butyric acid (GABA) is dependent on glutamate decarboxylases (GAD65 and GAD67), the enzymes that catalyze the decarboxylation of glutamate to GABA. Based on studies suggesting a role of the airway epithelial GABAergic system in asthma-related mucus overprodu...

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Detalles Bibliográficos
Autores principales: Wang, Guoqing, Wang, Rui, Ferris, Barbara, Salit, Jacqueline, Strulovici-Barel, Yael, Hackett, Neil R, Crystal, Ronald G
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988726/
https://www.ncbi.nlm.nih.gov/pubmed/21034448
http://dx.doi.org/10.1186/1465-9921-11-150