Cargando…

Smoking-mediated up-regulation of GAD67 expression in the human airway epithelium

BACKGROUND: The production of gamma-amino butyric acid (GABA) is dependent on glutamate decarboxylases (GAD65 and GAD67), the enzymes that catalyze the decarboxylation of glutamate to GABA. Based on studies suggesting a role of the airway epithelial GABAergic system in asthma-related mucus overprodu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Guoqing, Wang, Rui, Ferris, Barbara, Salit, Jacqueline, Strulovici-Barel, Yael, Hackett, Neil R, Crystal, Ronald G
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988726/ https://www.ncbi.nlm.nih.gov/pubmed/21034448 http://dx.doi.org/10.1186/1465-9921-11-150

Ejemplares similares

Down-Regulation of the Canonical Wnt β-Catenin Pathway in the Airway Epithelium of Healthy Smokers and Smokers with COPD
por: Wang, Rui, et al.
Publicado: (2011)

RNA-Seq quantification of the human small airway epithelium transcriptome
por: Hackett, Neil R, et al.
Publicado: (2012)

Genes associated with MUC5AC expression in small airway epithelium of human smokers and non-smokers
por: Wang, Guoqing, et al.
Publicado: (2012)

High Correlation of the Response of Upper and Lower Lobe Small Airway Epithelium to Smoking
por: Harvey, Ben-Gary, et al.
Publicado: (2013)

Cigarette smoking induces small airway epithelial epigenetic changes with corresponding modulation of gene expression
por: Buro-Auriemma, Lauren J, et al.
Publicado: (2013)

Waterpipe smoking induces epigenetic changes in the small airway epithelium
por: Walters, Matthew S., et al.
Publicado: (2017)

Biologic Phenotyping of the Human Small Airway Epithelial Response to Cigarette Smoking
por: Tilley, Ann E., et al.
Publicado: (2011)

Persistence of Smoking-Induced Dysregulation of MiRNA Expression in the Small Airway Epithelium Despite Smoking Cessation
por: Wang, Guoqing, et al.
Publicado: (2015)

Up-regulation of ACE2, the SARS-CoV-2 receptor, in asthmatics on maintenance inhaled corticosteroids
por: O’Beirne, Sarah L., et al.
Publicado: (2021)

Smoking Dysregulates the Human Airway Basal Cell Transcriptome at COPD Risk Locus 19q13.2
por: Ryan, Dorothy M., et al.
Publicado: (2014)

Smoking shifts human small airway epithelium club cells toward a lesser differentiated population
por: Rostami, Mahboubeh R., et al.
Publicado: (2021)

Expression of the SARS-CoV-2 ACE2 Receptor in the Human Airway Epithelium
por: Zhang, Haijun, et al.
Publicado: (2020)

Smoking accelerates aging of the small airway epithelium
por: Walters, Matthew S, et al.
Publicado: (2014)

Mandatory role of HMGA1 in human airway epithelial normal differentiation and post-injury regeneration
por: Zhang, Haijun, et al.
Publicado: (2018)

Cell-specific expression of lung disease risk-related genes in the human small airway epithelium
por: Zuo, Wu-lin, et al.
Publicado: (2020)

The Human Airway Epithelial Basal Cell Transcriptome
por: Hackett, Neil R., et al.
Publicado: (2011)

Expression of GAD67 and Novel GAD67 Splice Variants During Human Fetal Pancreas Development: GAD67 Expression in the Fetal Pancreas
por: Korpershoek, Esther, et al.
Publicado: (2007)

High apoptotic endothelial microparticle levels measured in asthma with elevated IgE and eosinophils
por: Strulovici-Barel, Yael, et al.
Publicado: (2023)

RFX3 Modulation of FOXJ1 regulation of cilia genes in the human airway epithelium
por: Didon, Lukas, et al.
Publicado: (2013)

An Analysis of the Cross-Reactivity of Autoantibodies to GAD65 and GAD67 in Diabetes
por: Jayakrishnan, Bindu, et al.
Publicado: (2011)

Intermittent exposure to whole cigarette smoke alters the differentiation of primary small airway epithelial cells in the air-liquid interface culture
por: Gindele, Julia A., et al.
Publicado: (2020)

Quality control in microarray assessment of gene expression in human airway epithelium
por: Raman, Tina, et al.
Publicado: (2009)

Disparate oxidant gene expression of airway epithelium compared to alveolar macrophages in smokers
por: Carolan, Brendan J, et al.
Publicado: (2009)

Widespread Sexual Dimorphism in the Transcriptome of Human Airway Epithelium in Response to Smoking
por: Yang, Chen Xi, et al.
Publicado: (2019)

Characterization of an immortalized human small airway basal stem/progenitor cell line with airway region-specific differentiation capacity
por: Wang, Guoqing, et al.
Publicado: (2019)

Reply to Sharma and Zeki: Does Vaping Increase Susceptibility to COVID-19?
por: Zhang, Haijun, et al.
Publicado: (2020)

A novel homozygous mutation in GAD1 gene described in a schizophrenic patient impairs activity and dimerization of GAD67 enzyme
por: Magri, Chiara, et al.
Publicado: (2018)

Two distinct mechanisms target GAD67 to vesicular pathways and presynaptic clusters
por: Kanaani, Jamil, et al.
Publicado: (2010)

Deep Learning-Based Classification of GAD67-Positive Neurons Without the Immunosignal
por: Yamashiro, Kotaro, et al.
Publicado: (2021)

Cognitive Impairment and the correlation with genetic Expression of GAD67, Gad65 and GABA beta2 Using Human Induced Pluripotent Stem Cells
por: Khalifa, D., et al.
Publicado: (2022)

Compartmentalization of GABA Synthesis by GAD67 Differs between Pancreatic Beta Cells and Neurons
por: Kanaani, Jamil, et al.
Publicado: (2015)

Immunoreactivity for GABA, GAD65, GAD67 and Bestrophin-1 in the Meninges and the Choroid Plexus: Implications for Non-Neuronal Sources for GABA in the Developing Mouse Brain
por: Tochitani, Shiro, et al.
Publicado: (2013)

Author Correction: A novel homozygous mutation in GAD1 gene described in a schizophrenic patient impairs activity and dimerization of GAD67 enzyme
por: Magri, Chiara, et al.
Publicado: (2020)

The effect of sodium thiopental as a GABA mimetic drug in neonatal period on expression of GAD65 and GAD67 genes in hippocampus of newborn and adult male rats
por: Naseri, Masoud, et al.
Publicado: (2017)

Molecular and functional characterization of GAD67-expressing, newborn granule cells in mouse dentate gyrus
por: Cabezas, Carolina, et al.
Publicado: (2013)

Hippocampal GAD67 Transduction Using rAAV8 Regulates Epileptogenesis in EL Mice
por: Shimazaki, Kuniko, et al.
Publicado: (2019)

Good MRI images: to Gad or not to Gad?
por: Steen, Henning, et al.
Publicado: (2007)

Basal cell origins of smoking-induced airway epithelial disorders
por: Shaykhiev, Renat, et al.
Publicado: (2014)

LRP1 loss in airway epithelium exacerbates smoke-induced oxidative damage and airway remodeling
por: Garcia-Arcos, Itsaso, et al.
Publicado: (2022)

In vivo knockdown of GAD67 in the amygdala disrupts fear extinction and the anxiolytic-like effect of diazepam in mice
por: Heldt, S A, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_4fogi71f1t2f2c01o27gm53mp5