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Structural basis for cooperative RNA binding and export complex assembly by HIV Rev

HIV replication requires nuclear export of unspliced viral RNAs to translate structural proteins and package genomic RNA. Export is mediated by cooperative binding of the Rev protein to the Rev response element (RRE) RNA, forming a highly specific oligomeric ribonucleoprotein (RNP) that binds to the...

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Detalles Bibliográficos
Autores principales: Daugherty, Matthew D., Liu, Bella, Frankel, Alan D.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988976/
https://www.ncbi.nlm.nih.gov/pubmed/20953181
http://dx.doi.org/10.1038/nsmb.1902