Regulation of sonic hedgehog-GLI1 downstream target genes PTCH1, Cyclin D2, Plakoglobin, PAX6 and NKX2.2 and their epigenetic status in medulloblastoma and astrocytoma

BACKGROUND: The Sonic hedgehog (Shh) signaling pathway is critical for cell growth and differentiation. Impairment of this pathway can result in both birth defects and cancer. Despite its importance in cancer development, the Shh pathway has not been thoroughly investigated in tumorigenesis of brain...

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Detalles Bibliográficos
Autores principales: Shahi, Mehdi H, Afzal, Mohammad, Sinha, Subrata, Eberhart, Charles G, Rey, Juan A, Fan, Xing, Castresana, Javier S
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989332/
https://www.ncbi.nlm.nih.gov/pubmed/21059263
http://dx.doi.org/10.1186/1471-2407-10-614

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989332/
https://www.ncbi.nlm.nih.gov/pubmed/21059263
http://dx.doi.org/10.1186/1471-2407-10-614

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