DNA Damage Induced by Alkylating Agents and Repair Pathways

The cytotoxic effects of alkylating agents are strongly attenuated by cellular DNA repair processes, necessitating a clear understanding of the repair mechanisms. Simple methylating agents form adducts at N- and O-atoms. N-methylations are removed by base excision repair, AlkB homologues, or nucleot...

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Detalles Bibliográficos
Autores principales: Kondo, Natsuko, Takahashi, Akihisa, Ono, Koji, Ohnishi, Takeo
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2010
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989456/
https://www.ncbi.nlm.nih.gov/pubmed/21113301
http://dx.doi.org/10.4061/2010/543531

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989456/
https://www.ncbi.nlm.nih.gov/pubmed/21113301
http://dx.doi.org/10.4061/2010/543531

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