New Strategies for the Next Generation of Matrix-Metalloproteinase Inhibitors: Selectively Targeting Membrane-Anchored MMPs with Therapeutic Antibodies

MMP intervention strategies have met with limited clinical success due to severe toxicities. In particular, treatment with broad-spectrum MMP-inhibitors (MMPIs) caused musculoskeletal pain and inflammation. Selectivity may be essential for realizing the clinical potential of MMPIs. Here we review di...

Descripción completa

Detalles Bibliográficos
Autores principales: Devy, Laetitia, Dransfield, Daniel T.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989751/
https://www.ncbi.nlm.nih.gov/pubmed/21152183
http://dx.doi.org/10.1155/2011/191670

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989751/
https://www.ncbi.nlm.nih.gov/pubmed/21152183
http://dx.doi.org/10.1155/2011/191670

Ejemplares similares