An examination of wild-type SOD1 in modulating the toxicity and aggregation of ALS-associated mutant SOD1

Mutations in superoxide dismutase 1 (SOD1) are associated with familial cases of amyotrophic lateral sclerosis (fALS). Studies in transgenic mice have suggested that wild-type (WT) SOD1 can modulate the toxicity of mutant SOD1. In the present study, we demonstrate that the effects of WT SOD1 on the...

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Detalles Bibliográficos
Autores principales: Prudencio, Mercedes, Durazo, Armando, Whitelegge, Julian P., Borchelt, David R.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989888/
https://www.ncbi.nlm.nih.gov/pubmed/20871097
http://dx.doi.org/10.1093/hmg/ddq408

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989888/
https://www.ncbi.nlm.nih.gov/pubmed/20871097
http://dx.doi.org/10.1093/hmg/ddq408

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