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Proteasome inhibition and its therapeutic potential in multiple myeloma
Due to an unmet clinical need for treatment, the first in class proteasome inhibitor, bortezomib, moved from drug discovery to FDA approval in multiple myeloma in an unprecedented eight years. In the wake of this rapid approval arose a large number of questions about its mechanism of action and toxi...
| Hlavní autoři: | , , |
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| Médium: | Text |
| Jazyk: | English |
| Vydáno: |
Dove Medical Press
2010
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| On-line přístup: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990320/ https://www.ncbi.nlm.nih.gov/pubmed/21116326 http://dx.doi.org/10.2147/BTT.S3419 |