Mammalian microRNAs predominantly act to decrease target mRNA levels

MicroRNAs (miRNAs) are endogenous ∼22-nucleotide RNAs that play important gene-regulatory roles by pairing to the mRNAs of protein-coding genes to direct their repression. Repression of these regulatory targets leads to decreased translational efficiency and/or decreased mRNA levels, but the relativ...

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Detalles Bibliográficos
Autores principales: Guo, Huili, Ingolia, Nicholas T., Weissman, Jonathan S., Bartel, David P.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990499/
https://www.ncbi.nlm.nih.gov/pubmed/20703300
http://dx.doi.org/10.1038/nature09267

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990499/
https://www.ncbi.nlm.nih.gov/pubmed/20703300
http://dx.doi.org/10.1038/nature09267

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