Central nervous system penetration and enhancement of temozolomide activity in childhood medulloblastoma models by poly(ADP-ribose) polymerase inhibitor AG-014699

BACKGROUND: Temozolomide shows activity against medulloblastoma, the most common malignant paediatric brain tumour. Poly(ADP-ribose) polymerase (PARP) inhibitors enhance temozolomide activity in extracranial adult and paediatric human malignancies. METHODS: We assessed the effect of AG-014699, a cli...

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Detalles Bibliográficos
Autores principales: Daniel, R A, Rozanska, A L, Mulligan, E A, Drew, Y, Thomas, H D, Castelbuono, D J, Hostomsky, Z, Plummer, E R, Tweddle, D A, Boddy, A V, Clifford, S C, Curtin, N J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990587/
https://www.ncbi.nlm.nih.gov/pubmed/20978505
http://dx.doi.org/10.1038/sj.bjc.6605946

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990587/
https://www.ncbi.nlm.nih.gov/pubmed/20978505
http://dx.doi.org/10.1038/sj.bjc.6605946

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