Fenretinide-dependent upregulation of death receptors through ASK1 and p38α enhances death receptor ligand-induced cell death in Ewing's sarcoma family of tumours

BACKGROUND: Sustained p38(MAPK) phosphorylation upregulates p75 neurotrophin (p75(NTR)) and induces apoptosis in Ewing's sarcoma family of tumours (ESFT). As fenretinide induces ESFT death through sustained p38(MAPK) phosphorylation, we hypothesised that this may be effected through upregulatio...

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Detalles Bibliográficos
Autores principales: White, D E, Burchill, S A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990598/
https://www.ncbi.nlm.nih.gov/pubmed/20877355
http://dx.doi.org/10.1038/sj.bjc.6605896

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990598/
https://www.ncbi.nlm.nih.gov/pubmed/20877355
http://dx.doi.org/10.1038/sj.bjc.6605896

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