Glutathione disulfide induces neural cell death via a 12-lipoxygenase pathway

Oxidized glutathione (GSSG) is commonly viewed as a byproduct of GSH metabolism. The pathophysiological significance of GSSG per se remains poorly understood. Adopting a microinjection approach to isolate GSSG elevation within the cell, this work identifies that GSSG can trigger neural HT4 cell deat...

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Detalles Bibliográficos
Autores principales: Park, Han-A, Khanna, Savita, Rink, Cameron, Gnyawali, Surya, Roy, Sashwati, Sen, Chandan K.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990696/
https://www.ncbi.nlm.nih.gov/pubmed/19373248
http://dx.doi.org/10.1038/cdd.2009.37

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990696/
https://www.ncbi.nlm.nih.gov/pubmed/19373248
http://dx.doi.org/10.1038/cdd.2009.37

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