Perturbation of adhesion molecule-mediated chondrocyte-matrix interactions by 4-hydroxynonenal binding: implication in osteoarthritis pathogenesis

INTRODUCTION: Objectives were to investigate whether interactions between human osteoarthritic chondrocytes and 4-hydroxynonenal (HNE)-modified type II collagen (Col II) affect cell phenotype and functions and to determine the protective role of carnosine (CAR) treatment in preventing these effects....

Descripción completa

Detalles Bibliográficos
Autores principales: El-Bikai, Rana, Welman, Mélanie, Margaron, Yoran, Côté, Jean-François, Macqueen, Luke, Buschmann, Michael D, Fahmi, Hassan, Shi, Qin, Maghni, Karim, Fernandes, Julio C, Benderdour, Mohamed
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991038/
https://www.ncbi.nlm.nih.gov/pubmed/20977750
http://dx.doi.org/10.1186/ar3173

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991038/
https://www.ncbi.nlm.nih.gov/pubmed/20977750
http://dx.doi.org/10.1186/ar3173

Ejemplares similares