Perturbation of adhesion molecule-mediated chondrocyte-matrix interactions by 4-hydroxynonenal binding: implication in osteoarthritis pathogenesis

INTRODUCTION: Objectives were to investigate whether interactions between human osteoarthritic chondrocytes and 4-hydroxynonenal (HNE)-modified type II collagen (Col II) affect cell phenotype and functions and to determine the protective role of carnosine (CAR) treatment in preventing these effects....

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Detalles Bibliográficos
Autores principales: El-Bikai, Rana, Welman, Mélanie, Margaron, Yoran, Côté, Jean-François, Macqueen, Luke, Buschmann, Michael D, Fahmi, Hassan, Shi, Qin, Maghni, Karim, Fernandes, Julio C, Benderdour, Mohamed
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991038/
https://www.ncbi.nlm.nih.gov/pubmed/20977750
http://dx.doi.org/10.1186/ar3173

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