Glycosylation Focuses Sequence Variation in the Influenza A Virus H1 Hemagglutinin Globular Domain

Antigenic drift in the influenza A virus hemagglutinin (HA) is responsible for seasonal reformulation of influenza vaccines. Here, we address an important and largely overlooked issue in antigenic drift: how does the number and location of glycosylation sites affect HA evolution in man? We analyzed...

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Detalles Bibliográficos
Autores principales: Das, Suman R., Puigbò, Pere, Hensley, Scott E., Hurt, Darrell E., Bennink, Jack R., Yewdell, Jonathan W.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991263/
https://www.ncbi.nlm.nih.gov/pubmed/21124818
http://dx.doi.org/10.1371/journal.ppat.1001211

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991263/
https://www.ncbi.nlm.nih.gov/pubmed/21124818
http://dx.doi.org/10.1371/journal.ppat.1001211

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