CpG Demethylation Enhances Alpha-Synuclein Expression and Affects the Pathogenesis of Parkinson's Disease

BACKGROUND: Alpha-synuclein (SNCA) gene expression is an important factor in the pathogenesis of Parkinson's disease (PD). Gene multiplication can cause inherited PD, and promoter polymorphisms that increase SNCA expression are associated with sporadic PD. CpG methylation in the promoter region...

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Detalles Bibliográficos
Autores principales: Matsumoto, Lumine, Takuma, Hiroshi, Tamaoka, Akira, Kurisaki, Hiroshi, Date, Hidetoshi, Tsuji, Shoji, Iwata, Atsushi
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991358/
https://www.ncbi.nlm.nih.gov/pubmed/21124796
http://dx.doi.org/10.1371/journal.pone.0015522

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991358/
https://www.ncbi.nlm.nih.gov/pubmed/21124796
http://dx.doi.org/10.1371/journal.pone.0015522

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