ALDH1L1 Inhibits Cell Motility Via Dephosphorylation of Cofilin by PP1 and PP2A

Here we report that ALDH1L1 (FDH, a folate enzyme with tumor suppressor-like properties) inhibits cell motility. The underlying mechanism involves F-actin stabilization, re-distribution of cytoplasmic actin towards strong preponderance of filamentous actin, and formation of actin stress fibers. A549...

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Detalles Bibliográficos
Autores principales: Oleinik, Natalia V., Krupenko, Natalia I., Krupenko, Sergey A.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992098/
https://www.ncbi.nlm.nih.gov/pubmed/20729910
http://dx.doi.org/10.1038/onc.2010.356

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992098/
https://www.ncbi.nlm.nih.gov/pubmed/20729910
http://dx.doi.org/10.1038/onc.2010.356

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