HIF-1α inhibition by siRNA or chetomin in human malignant glioma cells: effects on hypoxic radioresistance and monitoring via CA9 expression

BACKGROUND: Hypoxia induces activation of the HIF-1 pathway and is an essential characteristic of malignant gliomas. Hypoxia has been linked to tumor progression, therapy resistance and poor prognosis. However, little is known about the impact of HIF-1α inhibition on radioresistance of malignant gli...

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Detalles Bibliográficos
Autores principales: Kessler, Jacqueline, Hahnel, Antje, Wichmann, Henri, Rot, Swetlana, Kappler, Matthias, Bache, Matthias, Vordermark, Dirk
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992520/
https://www.ncbi.nlm.nih.gov/pubmed/21050481
http://dx.doi.org/10.1186/1471-2407-10-605

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992520/
https://www.ncbi.nlm.nih.gov/pubmed/21050481
http://dx.doi.org/10.1186/1471-2407-10-605

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