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A Soluble Guanylate Cyclase–Dependent Mechanism Is Involved in the Regulation of Net Hepatic Glucose Uptake by Nitric Oxide in Vivo

OBJECTIVE: We previously showed that elevating hepatic nitric oxide (NO) levels reduced net hepatic glucose uptake (NHGU) in the presence of portal glucose delivery, hyperglycemia, and hyperinsulinemia. The aim of the present study was to determine the role of a downstream signal, soluble guanylate...

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Detalles Bibliográficos
Autores principales: An, Zhibo, Winnick, Jason J., Farmer, Ben, Neal, Doss, Lautz, Margaret, Irimia, Jose M., Roach, Peter J., Cherrington, Alan D.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992759/
https://www.ncbi.nlm.nih.gov/pubmed/20823104
http://dx.doi.org/10.2337/db10-0138