Cargando…

Effects of PNPLA3 on Liver Fat and Metabolic Profile in Hispanic Children and Adolescents

OBJECTIVE: A genome-wide study of adults identified a variant of PNPLA3 (rs738409) associated with ∼twofold higher liver fat. The purpose of this study was to examine the influence of PNPLA3 genotype on liver fat and other related metabolic outcomes in obese Hispanic children and adolescents. RESEAR...

Descripción completa

Detalles Bibliográficos
Autores principales:	Goran, Michael I., Walker, Ryan, Le, Kim-Anne, Mahurkar, Swapna, Vikman, Susanna, Davis, Jaimie N., Spruijt-Metz, Donna, Weigensberg, Marc J., Allayee, Hooman
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2010
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992774/ https://www.ncbi.nlm.nih.gov/pubmed/20852027 http://dx.doi.org/10.2337/db10-0554

Ejemplares similares

Genetic and Clinical Markers of Elevated Liver Fat Content in Overweight and Obese Hispanic Children
por: Walker, Ryan W., et al.
Publicado: (2013)

Insulin Sensitivity as an Independent Predictor of Fat Mass Gain in Hispanic Adolescents
por: Adam, Tanja C., et al.
Publicado: (2009)

Modifying Influence of Dietary Sugar in the Relationship Between Cortisol and Visceral Adipose Tissue in Minority Youth
por: Gyllenhammer, Lauren E., et al.
Publicado: (2013)

Built environment associations with adiposity parameters among overweight and obese Hispanic youth
por: Hsieh, Stephanie, et al.
Publicado: (2015)

PNPLA3 Genotype, Arachidonic Acid Intake, and Unsaturated Fat Intake Influences Liver Fibrosis in Hispanic Youth with Obesity
por: Jones, Roshonda B., et al.
Publicado: (2021)

Fasting Indicators of Insulin Sensitivity: Effects of Ethnicity and Pubertal Status
por: Adam, Tanja C., et al.
Publicado: (2011)

Temporal Relationship Between Insulin Sensitivity and the Pubertal Decline in Physical Activity in Peripubertal Hispanic and African American Females
por: Spruijt-Metz, Donna, et al.
Publicado: (2013)

Meal Skipping Linked to Increased Visceral Adipose Tissue and Triglycerides in Overweight Minority Youth
por: House, Benjamin T., et al.
Publicado: (2013)

Optimal Elevation of β-Cell 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Compensatory Mechanism That Prevents High-Fat Diet–Induced β-Cell Failure
por: Turban, Sophie, et al.
Publicado: (2012)

Effects of Group-delivered Stress-reduction Guided Imagery on Salivary Cortisol, Salivary Amylase, and Stress Mood in Urban, Predominantly Latino Adolescents
por: Weigensberg, Marc J., et al.
Publicado: (2022)

Subcutaneous Adipose Tissue Macrophage Infiltration Is Associated With Hepatic and Visceral Fat Deposition, Hyperinsulinemia, and Stimulation of NF-κB Stress Pathway
por: Lê, Kim-Anne, et al.
Publicado: (2011)

Inhibition of Id1 Augments Insulin Secretion and Protects Against High-Fat Diet–Induced Glucose Intolerance
por: Åkerfeldt, Mia C., et al.
Publicado: (2011)

VMAT2 Safeguards β-Cells Against Dopamine Cytotoxicity Under High-Fat Diet–Induced Stress
por: Sakano, Daisuke, et al.
Publicado: (2020)

The Fatty Acid Receptor GPR40 Plays a Role in Insulin Secretion In Vivo After High-Fat Feeding
por: Kebede, Melkam, et al.
Publicado: (2008)

Sociocultural and Socioeconomic Influences on Type 2 Diabetes Risk in Overweight/Obese African-American and Latino-American Children and Adolescents
por: Hasson, Rebecca E., et al.
Publicado: (2013)

β-Cell Knockout of SENP1 Reduces Responses to Incretins and Worsens Oral Glucose Tolerance in High-Fat Diet–Fed Mice
por: Lin, Haopeng, et al.
Publicado: (2021)

Fructose-1,6-Bisphosphatase Overexpression in Pancreatic β-Cells Results in Reduced Insulin Secretion : A New Mechanism for Fat-Induced Impairment of β-Cell Function
por: Kebede, Melkam, et al.
Publicado: (2008)

Imagine HEALTH: results from a randomized pilot lifestyle intervention for obese Latino adolescents using Interactive Guided Imagery(SM)
por: Weigensberg, Marc J, et al.
Publicado: (2014)

The Peri-islet Basement Membrane, a Barrier to Infiltrating Leukocytes in Type 1 Diabetes in Mouse and Human
por: Korpos, Éva, et al.
Publicado: (2013)

Δ40 Isoform of p53 Controls β-Cell Proliferation and Glucose Homeostasis in Mice
por: Hinault, Charlotte, et al.
Publicado: (2011)

γ-Aminobutyric Acid (GABA) Is an Autocrine Excitatory Transmitter in Human Pancreatic β-Cells
por: Braun, Matthias, et al.
Publicado: (2010)

Persistence of Pre-Diabetes in Overweight and Obese Hispanic Children : Association With Progressive Insulin Resistance, Poor β-Cell Function, and Increasing Visceral Fat
por: Goran, Michael I., et al.
Publicado: (2008)

Postnatal Expansion of the Pancreatic β-Cell Mass Is Dependent on Survivin
por: Jiang, Yuying, et al.
Publicado: (2008)

Temporal relationships between adipocytokines and diabetes risk during puberty in Hispanic adolescents with obesity
por: Kayser, Brandon D., et al.
Publicado: (2015)

Membrane Potential-Dependent Inactivation of Voltage-Gated Ion Channels in α-Cells Inhibits Glucagon Secretion From Human Islets
por: Ramracheya, Reshma, et al.
Publicado: (2010)

Autoantigen-Induced Focusing of Vβ13(+) T Cells Precedes Onset of Autoimmune Diabetes in the LEW.1WR1 Rat
por: Eberwine, Ryan A., et al.
Publicado: (2014)

Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine β-Cells
por: Paul, Leena, et al.
Publicado: (2016)

Gestational Diabetes Mellitus From Inactivation of Prolactin Receptor and MafB in Islet β-Cells
por: Banerjee, Ronadip R., et al.
Publicado: (2016)

Elevated Mouse Hepatic Betatrophin Expression Does Not Increase Human β-Cell Replication in the Transplant Setting
por: Jiao, Yang, et al.
Publicado: (2014)

Interventions for improving metabolic risk in overweight Latino youth
por: Davis, Jaimie N, et al.
Publicado: (2010)

Guided Imagery Council: Feasibility, Acceptability, and Preliminary Effects of a Novel Group-Based Lifestyle Intervention in Predominantly Latino Adolescents
por: Weigensberg, Marc J, et al.
Publicado: (2019)

Neprilysin Is Required for Angiotensin-(1–7)’s Ability to Enhance Insulin Secretion via Its Proteolytic Activity to Generate Angiotensin-(1–2)
por: Brar, Gurkirat S., et al.
Publicado: (2017)

Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets
por: Blodgett, David M., et al.
Publicado: (2015)

Ethnic Differences in Pancreatic Fat Accumulation and Its Relationship With Other Fat Depots and Inflammatory Markers
por: Lê, Kim-Anne, et al.
Publicado: (2011)

Ongoing β-Cell Turnover in Adult Nonhuman Primates Is Not Adaptively Increased in Streptozotocin-Induced Diabetes
por: Saisho, Yoshifumi, et al.
Publicado: (2011)

Reduced Insulin Exocytosis in Human Pancreatic β-Cells With Gene Variants Linked to Type 2 Diabetes
por: Rosengren, Anders H., et al.
Publicado: (2012)

LA Sprouts Randomized Controlled Nutrition, Cooking and Gardening Program Reduces Obesity and Metabolic Risk in Latino Youth
por: Gatto, Nicole M., et al.
Publicado: (2015)

ADCY5 Couples Glucose to Insulin Secretion in Human Islets
por: Hodson, David J., et al.
Publicado: (2014)

Decreased Fetal Size Is Associated With β-Cell Hyperfunction in Early Life and Failure With Age
por: Chakravarthy, Manu V., et al.
Publicado: (2008)

miR-375 Targets 3′-Phosphoinositide–Dependent Protein Kinase-1 and Regulates Glucose-Induced Biological Responses in Pancreatic β-Cells
por: El Ouaamari, Abdelfattah, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_4ijc0ip9mb92tpj74midd99dti