The ERAD Inhibitor Eeyarestatin I Is a Bifunctional Compound with a Membrane-Binding Domain and a p97/VCP Inhibitory Group

BACKGROUND: Protein homeostasis in the endoplasmic reticulum (ER) has recently emerged as a therapeutic target for cancer treatment. Disruption of ER homeostasis results in ER stress, which is a major cause of cell death in cells exposed to the proteasome inhibitor Bortezomib, an anti-cancer drug ap...

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Detalles Bibliográficos
Autores principales: Wang, Qiuyan, Shinkre, Bidhan A., Lee, Jin-gu, Weniger, Marc A., Liu, Yanfen, Chen, Weiping, Wiestner, Adrian, Trenkle, William C., Ye, Yihong
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993181/
https://www.ncbi.nlm.nih.gov/pubmed/21124757
http://dx.doi.org/10.1371/journal.pone.0015479

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993181/
https://www.ncbi.nlm.nih.gov/pubmed/21124757
http://dx.doi.org/10.1371/journal.pone.0015479

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