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Modeling cardiac β-adrenergic signaling with normalized-Hill differential equations: comparison with a biochemical model

BACKGROUND: New approaches are needed for large-scale predictive modeling of cellular signaling networks. While mass action and enzyme kinetic approaches require extensive biochemical data, current logic-based approaches are used primarily for qualitative predictions and have lacked direct quantitat...

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Detalles Bibliográficos
Autores principales: Kraeutler, Matthew J, Soltis, Anthony R, Saucerman, Jeffrey J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993667/
https://www.ncbi.nlm.nih.gov/pubmed/21087478
http://dx.doi.org/10.1186/1752-0509-4-157