Dysfunction of Heterotrimeric Kinesin-2 in Rod Photoreceptor Cells and the Role of Opsin Mislocalization in Rapid Cell Death

Due to extensive elaboration of the photoreceptor cilium to form the outer segment, axonemal transport (IFT) in photoreceptors is extraordinarily busy, and retinal degeneration is a component of many ciliopathies. Functional loss of heterotrimeric kinesin-2, a major anterograde IFT motor, causes mis...

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Detalles Bibliográficos
Autores principales: Lopes, Vanda S., Jimeno, David, Khanobdee, Kornnika, Song, Xiaodan, Chen, Bryan, Nusinowitz, Steven, Williams, David S.
Formato: Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2010
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993738/
https://www.ncbi.nlm.nih.gov/pubmed/20926680
http://dx.doi.org/10.1091/mbc.E10-08-0715

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993738/
https://www.ncbi.nlm.nih.gov/pubmed/20926680
http://dx.doi.org/10.1091/mbc.E10-08-0715

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